Meloxicam is contraindicated in patients with a history of which condition?

Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) that is commonly used for pain relief and inflammation management. However, its use is contraindicated in patients with severe hepatic disease due to the way it is metabolized in the liver. In individuals with impaired liver function, the clearance of meloxicam may be significantly decreased, leading to an increased risk of adverse effects and potential toxicity. This is particularly concerning in acute settings where the management of pain needs to be balanced with the patient's overall health status.

Patients with severe hepatic disease may already have compromised organ function, and the additional burden of processing medications like meloxicam can exacerbate their condition. As a result, healthcare providers avoid prescribing this medication in such cases to ensure patient safety and prevent further complications.